A new study published in the New England
Journal of Medicine suggests an experimental immune system treatment that uses
the patient’s own cells might be an effective treatment for deadly skin cancers
called melanomas.
A 52-year-old man with recurrent melanoma,
which had already spread to a lung and a lymph node in his groin get the experimental
treatment. He was a lucky man in the end because its melanoma disappeared and
didn’t come back during a period of two years. The man was given an infusion of
its own, fortified immune system cells called CD4+ T cells.
Scientists at the Fred
Hutchinson Cancer
Research Center
in Seattle selected
CD4+ T cells from a sample of the patient’s white blood cells. These cells were
specifically programmed by the body to attack cancer. The researchers isolated
those types of cells and cloned them in their lab. After several months, they
infused 5 billion of the cloned cells back into the patient’s body.
“What we and others have thought might be
important is that we need to give patients more of these cancer-fighting T
cells which may be present in low frequency in most people,” researcher Cassian
Yee, MD, told WebMD. “You can do that
either by giving them a vaccine or, in our case, we took the cells out and grew
them and gave them back to him.”
“It's taken us many years to get to this
point,” he added.
The treatment had no side effects. But
researchers say this treatment will not always work because cancers try many
different tactics to defeat the immune system, the same source noted.
T-cell therapy is a promising one although
it’s hard to say if all the patients given the treatment will respond as well
as the man whose cancer was halted.
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